Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors.

ABSTRACT:

Background and purpose

Rotigotine acts as a dopamine receptor agonist with high affinity for the dopamine D2, D3, D4 and D5 receptors but with a low affinity for the dopamine D1 receptor. We have investigated this further in radioligand binding and functional studies and compared the profile of rotigotine with that of other drugs used in the treatment of Parkinson's disease (PD).

Experimental approach

The binding of rotigotine to human dopamine D1, D2, D3, D4 and D5 receptors was determined in radioligand binding studies using [(3)H]rotigotine and compared with that of standard antagonist radioligands. Functional interactions of rotigotine with human dopamine receptors was also determined.

Key results

[(3)H]rotigotine can be used as an agonist radioligand to label all

SUBMITTER: Wood M 

PROVIDER: S-EPMC4314200 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature