20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans.

ABSTRACT: Protein homeostasis (proteostasis) is one of the nodal points that need to be preserved to retain physiologic cellular/organismal balance. The ubiquitin-proteasome system (UPS) is responsible for the removal of both normal and damaged proteins, with the proteasome being the downstream effector. The proteasome is the major cellular protease with progressive impairment of function during aging and senescence. Despite the documented age-retarding properties of proteasome activation in various cellular models, simultaneous enhancement of the 20S core proteasome content, assembly, and function have never been reported in any multicellular organism. Consequently, the possible effects of the core proteasome modulation on organismal life span are elusive. In this study, we have achieved activation

SUBMITTER: Chondrogianni N 

PROVIDER: S-EPMC4314225 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature