Air pollution and percent emphysema identified by computed tomography in the Multi-Ethnic study of Atherosclerosis.

ABSTRACT:

Background

Air pollution is linked to low lung function and to respiratory events, yet little is known of associations with lung structure.

Objectives

We examined associations of particulate matter (PM2.5, PM10) and nitrogen oxides (NOx) with percent emphysema-like lung on computed tomography (CT).

Methods

The Multi-Ethnic Study of Atherosclerosis (MESA) recruited participants (45-84 years of age) in six U.S. states. Percent emphysema was defined as lung regions < -910 Hounsfield Units on cardiac CT scans acquired following a highly standardized protocol. Spirometry was also conducted on a subset. Individual-level 1- and 20-year average air pollution exposures were estimated using spatiotemporal models that included cohort-specific measurements. Multivariable regressi

SUBMITTER: Adar SD 

PROVIDER: S-EPMC4314244 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature