Human health effects of dichloromethane: key findings and scientific issues.

ABSTRACT:

Background

The U.S. EPA's Integrated Risk Information System (IRIS) completed an updated toxicological review of dichloromethane in November 2011.

Objectives

In this commentary we summarize key results and issues of this review, including exposure sources, identification of potential health effects, and updated physiologically based pharmacokinetic (PBPK) modeling.

Methods

We performed a comprehensive review of primary research studies and evaluation of PBPK models.

Discussion

Hepatotoxicity was observed in oral and inhalation exposure studies in several studies in animals; neurological effects were also identified as a potential area of concern. Dichloromethane was classified as likely to be carcinogenic in humans based primarily on evidence of carcinogenicity

SUBMITTER: Schlosser PM 

PROVIDER: S-EPMC4314245 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature