Early-life exposure to organophosphate pesticides and pediatric respiratory symptoms in the CHAMACOS cohort.

ABSTRACT:

Background

Although pesticide use is widespread, the possible effect of early-life exposure to organophosphate (OP) on pediatric respiratory health is not well described.

Objectives

We investigated the relationship between early-life exposure to OPs and respiratory outcomes.

Methods

Participants included 359 mothers and children from the CHAMACOS birth cohort. Dialkyl phosphate (DAP) metabolites of OP pesticides, specifically diethyl (DE) and dimethyl (DM) phosphate metabolites, were measured in urine from mothers twice during pregnancy (mean = 13 and 26 weeks gestation) and from children five times during childhood (0.5-5 years). Childhood DAP concentrations were estimated by the area under curve (AUC). Mothers reported their child's respiratory symptoms at 5 and 7 y

SUBMITTER: Raanan R 

PROVIDER: S-EPMC4314248 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature