TMS enhances retention of a motor skill in Parkinson's disease.

ABSTRACT:

Background

In Parkinson's disease (PD), skill retention is poor, even when acquisition rate is generally preserved. Recent work in normal subjects suggests that 5 Hz-repetitive transcranial magnetic stimulation (5Hz-rTMS) may induce phenomena of long-term potentiation at the cortical level.

Objective/hypothesis

We thus verified whether, in PD, 5Hz-rTMS enhances retention of a visuo-motor skill that involves the activity of the right posterior parietal cortex.

Methods

A group of patients with PD was tested in two two-day sessions, separated by one week (treatment and placebo sessions). The first day of each session, they learned to adapt their movements to a step-wise 60° visual rotation. Immediately after the task, either real 5Hz-rTMS (treatment) or sham (placebo) st

SUBMITTER: Moisello C 

PROVIDER: S-EPMC4314317 | biostudies-literature | 2015 Mar-Apr

REPOSITORIES: biostudies-literature