Follow-up to genome-wide linkage and admixture mapping studies implicates components of the extracellular matrix in susceptibility to and size of uterine fibroids.

ABSTRACT:

Objective

To conduct a follow-up association mapping to independent genome-wide linkage and admixture mapping studies of uterine leiomyoma.

Design

Case-control, cross-sectional study.

Setting

Not applicable.

Patient(s)

A total of 1,045 premenopausal North American participants in the National Institute of Environmental Health Sciences Uterine Fibroid Study.

Intervention(s)

None.

Main outcome measure(s)

We genotyped 2,772 single-nucleotide polymorphisms from candidate genes located in peaks of linkage (2q37, 3p21, 5p13, 10p11, 11p15, 12q14, and 17q25) or admixture linkage disequilibrium (2q37, 4p16.1, and 10q26) mapping and reported to have regulated expression in uterine fibroids.

Result(s)

We report significant associations of variant memb

SUBMITTER: Aissani B 

PROVIDER: S-EPMC4314358 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature