Global analysis of methylation profiles from high resolution CpG data.

ABSTRACT: New high throughput technologies are now enabling simultaneous epigenetic profiling of DNA methylation at hundreds of thousands of CpGs across the genome. A problem of considerable practical interest is identification of large scale, global changes in methylation that are associated with environmental variables, clinical outcomes, or other experimental conditions. However, there has been little statistical research on methods for global methylation analysis using technologies with individual CpG resolution. To address this critical gap in the literature, we develop a new strategy for global analysis of methylation profiles using a functional regression approach wherein we approximate either the density or the cumulative distribution function (CDF) of the methylation values for each individ

SUBMITTER: Zhao N 

PROVIDER: S-EPMC4314375 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature