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Transgenerational effects of binge drinking in a primate model: implications for human health.


ABSTRACT: To determine if binge ethanol consumption before ovulation affects oocyte quality, gene expression, and subsequent embryo development.Binge levels of ethanol were given twice weekly for 6 months, followed by a standard in vitro fertilization cycle and subsequent natural mating.National primate research center.Adult female rhesus monkeys.Binge levels of ethanol, given twice weekly for 6 months before a standard in vitro fertilization cycle with or without embryo culture. With in vivo development, ethanol treatment continued until pregnancy was identified.Oocyte and cumulus/granulosa cell gene expression, embryo development to blastocyst, and pregnancy rate.Embryo development in vitro was reduced; changes were found in oocyte and cumulus cell gene expression; and spontaneous abortion during very early gestation increased.This study provides evidence that binge drinking can affect the developmental potential of oocytes even after alcohol consumption has ceased.

SUBMITTER: VandeVoort CA 

PROVIDER: S-EPMC4314404 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Transgenerational effects of binge drinking in a primate model: implications for human health.

VandeVoort Catherine A CA   Grimsrud Kristin N KN   Midic Uros U   Mtango Namdori N   Latham Keith E KE  

Fertility and sterility 20141206 2


<h4>Objective</h4>To determine if binge ethanol consumption before ovulation affects oocyte quality, gene expression, and subsequent embryo development.<h4>Design</h4>Binge levels of ethanol were given twice weekly for 6 months, followed by a standard in vitro fertilization cycle and subsequent natural mating.<h4>Setting</h4>National primate research center.<h4>Animal(s)</h4>Adult female rhesus monkeys.<h4>Intervention(s)</h4>Binge levels of ethanol, given twice weekly for 6 months before a stan  ...[more]

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