Comparing two correlated C indices with right-censored survival outcome: a one-shot nonparametric approach.

ABSTRACT: The area under the receiver operating characteristic curve is often used as a summary index of the diagnostic ability in evaluating biomarkers when the clinical outcome (truth) is binary. When the clinical outcome is right-censored survival time, the C index, motivated as an extension of area under the receiver operating characteristic curve, has been proposed by Harrell as a measure of concordance between a predictive biomarker and the right-censored survival outcome. In this work, we investigate methods for statistical comparison of two diagnostic or predictive systems, of which they could either be two biomarkers or two fixed algorithms, in terms of their C indices. We adopt a U-statistics-based C estimator that is asymptotically normal and develop a nonparametric analytical approach to

SUBMITTER: Kang L 

PROVIDER: S-EPMC4314453 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature