SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function.

ABSTRACT:

Objective

SIRT1 has been proposed to be a key signaling node linking changes in energy metabolism to transcriptional adaptations. Although SIRT1 overexpression is protective against diverse metabolic complications, especially in response to high-fat diets, studies aiming to understand the etiology of such benefits are scarce. Here, we aimed to identify the key tissues and mechanisms implicated in the beneficial effects of SIRT1 on glucose homeostasis.

Methods

We have used a mouse model of moderate SIRT1 overexpression, under the control of its natural promoter, to evaluate glucose homeostasis and thoroughly characterize how different tissues could influence insulin sensitivity.

Results

Mice with moderate overexpression of SIRT1 exhibit better glucose tolerance and ins

SUBMITTER: Boutant M 

PROVIDER: S-EPMC4314542 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature