Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction.

ABSTRACT:

Objective

Glucagon is a hormone with metabolic actions that maintains normoglycemia during the fasting state. Strategies enabling either inhibition or activation of glucagon receptor (Gcgr) signaling are being explored for the treatment of diabetes or obesity. However, the cardiovascular consequences of manipulating glucagon action are poorly understood.

Methods

We assessed infarct size and the following outcomes following left anterior descending (LAD) coronary artery ligation; cardiac gene and protein expression, acylcarnitine profiles, and cardiomyocyte survival in normoglycemic non-obese wildtype mice, and in newly generated mice with selective inactivation of the cardiomyocyte Gcgr. Complementary experiments analyzed Gcgr signaling and cell survival in cardiomyocyte cul

SUBMITTER: Ali S 

PROVIDER: S-EPMC4314543 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature