Altered functional connectivity within the central reward network in overweight and obese women.

ABSTRACT:

Background/objectives

Neuroimaging studies in obese subjects have identified abnormal activation of key regions of central reward circuits, including the nucleus accumbens (NAcc), in response to food-related stimuli. We aimed to examine whether women with elevated body mass index (BMI) show structural and resting state (RS) functional connectivity alterations within regions of the reward network.

Subjects/methods

Fifty healthy, premenopausal women, 19 overweight and obese (high BMI=26-38 kg m(-2)) and 31 lean (BMI=19-25 kg m(-2)) were selected from the University of California Los Angeles' Oppenheimer Center for Neurobiology of Stress database. Structural and RS functional scans were collected. Group differences in grey matter volume (GMV) of the NAcc, oscillation dynamics o

SUBMITTER: Coveleskie K 

PROVIDER: S-EPMC4314578 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature