Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.

ABSTRACT:

Importance

Because APOE locus variants contribute to risk of late-onset Alzheimer disease (LOAD) and to differences in age at onset (AAO), it is important to know whether other established LOAD risk loci also affect AAO in affected participants.

Objectives

To investigate the effects of known Alzheimer disease risk loci in modifying AAO and to estimate their cumulative effect on AAO variation using data from genome-wide association studies in the Alzheimer Disease Genetics Consortium.

Design, setting, and participants

The Alzheimer Disease Genetics Consortium comprises 14 case-control, prospective, and family-based data sets with data on 9162 participants of white race/ethnicity with Alzheimer disease occurring after age 60 years who also had complete AAO information,

SUBMITTER: Naj AC 

PROVIDER: S-EPMC4314944 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature