Widespread increase of functional connectivity in Parkinson's disease with tremor: a resting-state FMRI study.

ABSTRACT: Parkinson's disease (PD) is a clinically heterogeneous disease in the symptomatology dominated by tremor, akinesia, or rigidity. Focusing on PD patients with tremor, this study investigated their discoordination patterns of spontaneous brain activity by combining voxel-wise centrality, seed-based functional connectivity, and network efficiency methods. Sixteen patients and 20 matched healthy controls (HCs) were recruited and underwent structural and resting-state functional MRI scan. Compared with the HCs, the patients exhibited increased centrality in the frontal, parietal, and occipital regions while decreased centrality in the cerebellum anterior lobe and thalamus. Seeded at these regions, a distributed network was further identified that encompassed cortical (default mode network, sens

SUBMITTER: Zhang D 

PROVIDER: S-EPMC4315047 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature