Anti-group B Streptococcus antibody in infants born to mothers with human immunodeficiency virus (HIV) infection.

ABSTRACT:

Background

HIV-exposed uninfected infants have increased infection risk and mortality compared to HIV-unexposed infants. HIV-exposed infants may be at increased risk of invasive GBS disease due to reduced maternal antibody against GBS.

Methods

We quantified antibodies that bind to the surface of whole Group B Streptococcus (GBS) of serotypes Ia, Ib, II, III and V using novel flow cytometry assays in South African HIV-infected and non-infected mothers and their uninfected infants. Antibody-mediated complement C3b/iC3b deposition onto GBS of these serotypes was also quantified by a novel flow cytometry assay.

Results

Geometric mean concentration (GMC) of both surface-binding anti-GBS antibody and antibody-mediated complement deposition onto GBS were reduced in HIV-infec

SUBMITTER: Le Doare K 

PROVIDER: S-EPMC4315133 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature