Ultra-high resolution diffusion tensor imaging of the microscopic pathways of the medial temporal lobe.

ABSTRACT: Diseases involving the medial temporal lobes (MTL) such as Alzheimer's disease and mesial temporal sclerosis pose an ongoing diagnostic challenge because of the difficulty in identifying conclusive imaging features, particularly in pre-clinical states. Abnormal neuronal connectivity may be present in the circuitry of the MTL, but current techniques cannot reliably detect those abnormalities. Diffusion tensor imaging (DTI) has shown promise in defining putative abnormalities in connectivity, but DTI studies of the MTL performed to date have shown neither dramatic nor consistent differences across patient populations. Conventional DTI methodology provides an inadequate depiction of the complex microanatomy present in the medial temporal lobe because of a typically employed low isotropic reso

SUBMITTER: Zeineh MM 

PROVIDER: S-EPMC4315156 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature