TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity.

ABSTRACT: Despite overwhelming evidence that transcriptional activation by TP53 is critical for its tumor suppressive activity, the mechanisms by which TP53 engages the genome in the context of chromatin to activate transcription are not well understood. Using a compendium of novel and existing genome-wide data sets, we examined the relationship between TP53 binding and the dynamics of the local chromatin environment. Our analysis revealed three distinct categories of TP53 binding events that differ based on the dynamics of the local chromatin environment. The first class of TP53 binding events occurs near transcriptional start sites (TSS) and is defined by previously characterized promoter-associated chromatin modifications. The second class comprises a large cohort of preestablished, promoter-dist

SUBMITTER: Sammons MA 

PROVIDER: S-EPMC4315292 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature