Parente2: a fast and accurate method for detecting identity by descent.

ABSTRACT: Identity-by-descent (IBD) inference is the problem of establishing a genetic connection between two individuals through a genomic segment that is inherited by both individuals from a recent common ancestor. IBD inference is an important preceding step in a variety of population genomic studies, ranging from demographic studies to linking genomic variation with phenotype and disease. The problem of accurate IBD detection has become increasingly challenging with the availability of large collections of human genotypes and genomes: Given a cohort's size, a quadratic number of pairwise genome comparisons must be performed. Therefore, computation time and the false discovery rate can also scale quadratically. To enable accurate and efficient large-scale IBD detection, we present Parente2, a nov

SUBMITTER: Rodriguez JM 

PROVIDER: S-EPMC4315301 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature