Polymorphisms in melanoma differentiation-associated gene 5 link protein function to clearance of hepatitis C virus.

ABSTRACT:

Unlabelled

Among patients newly infected with hepatitis C virus (HCV), only 20-30% clear the infection spontaneously. In the remaining 70% the infection persists, causing chronic liver inflammation and disease. It is well established that polymorphisms in host genes, especially in components of the innate immune response, contribute to the phenomenon of spontaneous HCV clearance. Retinoic acid inducible gene-I (RIG-I)-like helicases such as melanoma differentiation-associated gene 5 (MDA-5) are cytoplasmic sensors of viral RNA that are critical for triggering innate immune responses after infection with RNA viruses. We analyzed 14 nonsynonymous single-nucleotide polymorphisms in RIG-I-like helicase-pathway-genes comparing European patients who spontaneously cleared HCV (n = 285) or

SUBMITTER: Hoffmann FS 

PROVIDER: S-EPMC4315306 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature