Exploring bacterial organelle interactomes: a model of the protein-protein interaction network in the Pdu microcompartment.

ABSTRACT: Bacterial microcompartments (MCPs) are protein-bound organelles that carry out diverse metabolic pathways in a wide range of bacteria. These supramolecular assemblies consist of a thin outer protein shell, reminiscent of a viral capsid, which encapsulates sequentially acting enzymes. The most complex MCP elucidated so far is the propanediol utilizing (Pdu) microcompartment. It contains the reactions for degrading 1,2-propanediol. While several experimental studies on the Pdu system have provided hints about its organization, a clear picture of how all the individual components interact has not emerged yet. Here we use co-evolution-based methods, involving pairwise comparisons of protein phylogenetic trees, to predict the protein-protein interaction (PPI) network governing the assembly of t

SUBMITTER: Jorda J 

PROVIDER: S-EPMC4315436 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature