Peripheral blood IRF1 expression as a marker for glucocorticoid sensitivity.

ABSTRACT:

Objective

Despite of the common usage of glucocorticoids (GCs), a significant portion of asthma patients exhibit GC insensitivity. This could be mediated by diverse mechanisms, including genomics. Recent work has suggested that measuring changes in gene expression may provide more predictive information about GC insensitivity than baseline gene expression alone, and that expression changes in peripheral blood may be reflective of those in the airway.

Methods

We performed in silico discovery using gene expression omnibus (GEO) data that evaluated GC effect on gene expression in multiple tissue types. Subsequently, candidate genes whose expression levels are affected by GC were examined in cell lines and in primary cells derived from human airway and blood.

Results

Thro

SUBMITTER: Chapin WJ 

PROVIDER: S-EPMC4315702 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature