Cortical and trabecular bone in pediatric end-stage kidney disease.

ABSTRACT:

Background

Cortical bone represents nearly 80 % of human bone mass and is the major determinant of bone strength; however, cortical bone parameters and their relationship to trabecular bone in the pediatric chronic kidney disease (CKD) population have not been evaluated.

Methods

Biochemical values and cortical and trabecular bone parameters were assessed in 22 pediatric dialysis patients: 12 with high and 10 with normal to low trabecular bone turnover.

Results

Trabecular bone turnover and osteoid volume correlated with parathyroid hormone (PTH) levels (r = 0.86, p < 0.01 and r = 0.93, p < 0.01, respectively). Internal cortical osteonal bone formation rate was directly related to alkaline phosphatase (r = 0.45, p < 0.05) and inversely related to insulin-like growth fac

SUBMITTER: Carvalho CG 

PROVIDER: S-EPMC4315739 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature