Differential platelet levels affect response to taxane-based therapy in ovarian cancer.

ABSTRACT:

Purpose

We hypothesized that platelet levels during therapy could serve as a biomarker for response to therapy and that manipulation of platelet levels could impact responsiveness to chemotherapy.

Experimental design

The medical records of patients with recurrent or progressive ovarian cancer were retrospectively queried for changes in platelet and CA-125 levels during primary therapy. In vitro coculture experiments and in vivo orthotopic models of human ovarian cancer in mice were used to test the effect of modulating platelet levels on tumor growth and responsiveness to docetaxel.

Results

Thrombocytosis at the diagnosis of ovarian cancer was correlated with decreased interval to progression (P = 0.05) and median overall survival (P = 0.007). Mean platelet levels cor

SUBMITTER: Bottsford-Miller J 

PROVIDER: S-EPMC4315757 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature