Factors affecting reorganisation of memory encoding networks in temporal lobe epilepsy.

ABSTRACT:

Aims

In temporal lobe epilepsy (TLE) due to hippocampal sclerosis reorganisation in the memory encoding network has been consistently described. Distinct areas of reorganisation have been shown to be efficient when associated with successful subsequent memory formation or inefficient when not associated with successful subsequent memory. We investigated the effect of clinical parameters that modulate memory functions: age at onset of epilepsy, epilepsy duration and seizure frequency in a large cohort of patients.

Methods

We studied 53 patients with unilateral TLE and hippocampal sclerosis (29 left). All participants performed a functional magnetic resonance imaging memory encoding paradigm of faces and words. A continuous regression analysis was used to investigate the effec

SUBMITTER: Sidhu MK 

PROVIDER: S-EPMC4315807 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature