HIF-1α -1790G>A polymorphism significantly increases the risk of digestive tract cancer: a meta-analysis.

ABSTRACT:

Aim

To investigate the association between hypoxia-inducible factor-1α (HIF-1α) polymorphisms (-1772C>T and -1790G>A) and the risk of digestive tract cancer.

Methods

A total of 13 eligible studies were retrieved from PubMed, EMBASE, and the China National Knowledge Infrastructure database. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the associations.

Results

By pooling the eligible studies, we found that the HIF-1α -1772C>T polymorphism was not associated with the risk of developing digestive tract cancer (dominant comparison, OR: 1.156; 95%CI: 0.839-1.593; P heterogeneity = 0.007), and no significant association was found in the Asian population or the Caucasian population. However, for the -1790G>A polymorphis

SUBMITTER: Sun X 

PROVIDER: S-EPMC4316108 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature