Single nucleotide polymorphisms in DNA repair genes as risk factors associated to prostate cancer progression.

ABSTRACT:

Background

Besides serum levels of PSA, there is a lack of prostate cancer specific biomarkers. It is need to develop new biological markers associated with the tumor behavior which would be valuable to better individualize treatment. The aim of this study was to elucidate the relationship between single nucleotide polymorphisms (SNPs) in genes involved in DNA repair and prostate cancer progression.

Methods

A total of 494 prostate cancer patients from a Spanish multicenter study were genotyped for 10 SNPs in XRCC1, ERCC2, ERCC1, LIG4, ATM and TP53 genes. The SNP genotyping was made in a Biotrove OpenArray® NT Cycler. Clinical tumor stage, diagnostic PSA serum levels, and Gleason score at diagnosis were obtained for all participants. Genotypic and allelic frequencies were det

SUBMITTER: Henriquez-Hernandez LA 

PROVIDER: S-EPMC4316399 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature