NSAIDs, statins, low-dose aspirin and PPIs, and the risk of oesophageal adenocarcinoma among patients with Barrett's oesophagus: a population-based case-control study.

ABSTRACT:

Objectives

Non-steroidal anti-inflammatory drugs (NSAIDs), proton pump inhibitors (PPIs), low-dose aspirin and statins may decrease the risk of oesophageal adenocarcinoma (OAC) among patients with Barrett's oesophagus (BO). However, previous studies did not adequately address bias and confounding. Our objective was to estimate the risk of OAC among patients with BO exposed to NSAIDs, statins and PPIs.

Design

Case-control study nested within a BO cohort.

Setting

Two primary care databases (the UK and the Netherlands (NL)).

Participants

Cases were adults ≥18 years of age with OAC or high-grade dysplasia (HGD) diagnosis ≥1 year after BO diagnosis. Controls were matched on age, sex, year of BO diagnosis and database.

Exposure

Drug use was assessed from BO di

SUBMITTER: Masclee GM 

PROVIDER: S-EPMC4316430 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature