Placebo effects in trials evaluating 12 selected minimally invasive interventions: a systematic review and meta-analysis.

ABSTRACT:

Objectives

To analyse the impact of placebo effects on outcome in trials of selected minimally invasive procedures and to assess reported adverse events in both trial arms.

Design

A systematic review and meta-analysis.

Data sources and study selection

We searched MEDLINE and Cochrane library to identify systematic reviews of musculoskeletal, neurological and cardiac conditions published between January 2009 and January 2014 comparing selected minimally invasive with placebo (sham) procedures. We searched MEDLINE for additional randomised controlled trials published between January 2000 and January 2014.

Data synthesis

Effect sizes (ES) in the active and placebo arms in the trials' primary and pooled secondary end points were calculated. Linear regression was us

SUBMITTER: Holtedahl R 

PROVIDER: S-EPMC4316431 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature