Stress-related genes and heroin addiction: a role for a functional FKBP5 haplotype.

ABSTRACT:

Background

Stress is a critical risk factor affecting both the development of and the relapse to drug addictions. Drug addictions are caused by genetic, environmental and drug-induced factors. The objective of this hypothesis-driven association study was to determine if genetic variants in stress-related genes are associated with heroin addiction.

Methods

112 selected genetic variants in 26 stress-related genes were genotyped in 852 case subjects and 238 controls of predominantly European ancestry. The case subjects are former heroin addicts with a history of at least one year of daily multiple uses of heroin, treated at a methadone maintenance treatment program (MMTP). The two most promising SNPs were subsequently tested in an African-American sample comprising of 314 cases

SUBMITTER: Levran O 

PROVIDER: S-EPMC4316666 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature