Associations between time spent sitting and cancer-related biomarkers in postmenopausal women: an exploration of effect modifiers.

ABSTRACT:

Purpose

Despite evidence that prolonged periods of sitting may influence biological mediators of cancer development, few studies have considered these relationships in a cancer-specific context.

Methods

This cross-sectional study included 755 postmenopausal women enrolled in an ancillary study of the Women's Health Initiative. Plasma levels of Insulin-like growth factor-I (IGF-I), IGF-binding protein-3, leptin, insulin, C-peptide, C-reactive protein (CRP), and Interleukin (IL)-6 were measured. The time spent sitting per day was categorized as quartiles (Qs). The relationships between sedentary time and biomarkers were modified by race, physical activity, and exogenous estrogen use.

Results

IGF-I levels among African American (AA) women were higher than those of white

SUBMITTER: Paxton RJ 

PROVIDER: S-EPMC4316818 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature