Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan.

ABSTRACT:

Objective

To examine familial aggregation of gout and to estimate the heritability and environmental contributions to gout susceptibility in the general population.

Methods

Using data from the National Health Insurance (NHI) Research Database in Taiwan, we conducted a nationwide cross-sectional study of data collected from 22 643 748 beneficiaries of the NHI in 2004; among them 1 045 059 individuals had physician-diagnosed gout. We estimated relative risks (RR) of gout in individuals with affected first-degree and second-degree relatives and relative contributions of genes (heritability), common environment shared by family members and non-shared environment to gout susceptibility.

Results

RRs for gout were significantly higher in individuals with affected first-degre

SUBMITTER: Kuo CF 

PROVIDER: S-EPMC4316854 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature