Drug survival on TNF inhibitors in patients with rheumatoid arthritis comparison of adalimumab, etanercept and infliximab.

ABSTRACT:

Objective

To compare drug survival on adalimumab, etanercept and infliximab in patients with rheumatoid arthritis (RA).

Methods

Patients with RA (n=9139; 76% women; mean age 56 years) starting their first tumour necrosis factor (TNF) inhibitor between 2003 and 2011 were identified in the Swedish Biologics Register (ARTIS). Data were collected through 31 December 2011. Drug survival over up to 5 years of follow-up was compared overall and by period of treatment start (2003-2005/2006-2009; n=3168/4184) with adjustment for age, sex, education, period, health assessment questionnaire (HAQ), disease duration, concomitant disease modifying antirheumatic drug (DMARD) treatment and general frailty (using hospitalisation history as proxy).

Results

During 20 198 person-years (m

SUBMITTER: Neovius M 

PROVIDER: S-EPMC4316855 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature