Large-scale genomic sequencing of extraintestinal pathogenic Escherichia coli strains.

ABSTRACT: Large-scale bacterial genome sequencing efforts to date have provided limited information on the most prevalent category of disease: sporadically acquired infections caused by common pathogenic bacteria. Here, we performed whole-genome sequencing and de novo assembly of 312 blood- or urine-derived isolates of extraintestinal pathogenic (ExPEC) Escherichia coli, a common agent of sepsis and community-acquired urinary tract infections, obtained during the course of routine clinical care at a single institution. We find that ExPEC E. coli are highly genomically heterogeneous, consistent with pan-genome analyses encompassing the larger species. Investigation of differential virulence factor content and antibiotic resistance phenotypes reveals markedly different profiles among lineages and amon

SUBMITTER: Salipante SJ 

PROVIDER: S-EPMC4317167 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature