Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice.

ABSTRACT:

Rationale

Multiple biological mechanisms contribute to the efficacy of cardiac cell therapy. Most prominent among these are direct heart muscle and blood vessel regeneration from transplanted cells, as opposed to paracrine enhancement of tissue preservation and/or recruitment of endogenous repair.

Objective

Human cardiac progenitor cells, cultured as cardiospheres (CSps) or as CSp-derived cells (CDCs), have been shown to be capable of direct cardiac regeneration in vivo. Here we characterized paracrine effects in CDC transplantation and investigated their relative importance versus direct differentiation of surviving transplanted cells.

Methods and results

In vitro, many growth factors were found in media conditioned by human adult CSps and CDCs; CDC-conditioned media

SUBMITTER: Chimenti I 

PROVIDER: S-EPMC4317351 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature