Neural substrates of self-regulatory control in children and adults with Tourette syndrome.

ABSTRACT:

Objective

To identify the neural substrate of self-regulatory control in children and adults with Tourette syndrome (TS).

Method

We used event-related functional magnetic resonance imaging (fMRI) to study the neural correlates of cognitive self-regulation during the Simon task. Forty-two people from The Tic Disorder Specialty Clinic who met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for diagnosis with TS (24 children; 18 adults) were compared with 37 control subjects (19 children; 18 adults). Patients with TS were excluded from participation if they had any Axis I psychiatric disorder other than obsessive-compulsive disorder (OCD) or attention-deficit hyperactivity disorder (ADHD) prior to the onset of TS. Control participants were exc

SUBMITTER: Raz A 

PROVIDER: S-EPMC4317356 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature