Macrotene chromosomes provide insights to a new mechanism of high-order gene amplification in eukaryotes.

ABSTRACT: Copy number variation of chromosomal segments is now recognized as a major source of genetic polymorphism within natural populations of eukaryotes, as well as a possible cause of genetic diseases in humans, including cancer, but its molecular bases remain incompletely understood. In the baker's yeast Saccharomyces cerevisiae, a variety of low-order amplifications (segmental duplications) were observed after adaptation to limiting environmental conditions or recovery from gene dosage imbalance, and interpreted in terms of replication-based mechanisms associated or not with homologous recombination. Here we show the emergence of novel high-order amplification structures, with corresponding overexpression of embedded genes, during evolution under favourable growth conditions of severely unfit

SUBMITTER: Thierry A 

PROVIDER: S-EPMC4317496 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature