A major controversy in codon-anticodon adaptation resolved by a new codon usage index.

ABSTRACT: Two alternative hypotheses attribute different benefits to codon-anticodon adaptation. The first assumes that protein production is rate limited by both initiation and elongation and that codon-anticodon adaptation would result in higher elongation efficiency and more efficient and accurate protein production, especially for highly expressed genes. The second claims that protein production is rate limited only by initiation efficiency but that improved codon adaptation and, consequently, increased elongation efficiency have the benefit of increasing ribosomal availability for global translation. To test these hypotheses, a recent study engineered a synthetic library of 154 genes, all encoding the same protein but differing in degrees of codon adaptation, to quantify the effect of different

SUBMITTER: Xia X 

PROVIDER: S-EPMC4317663 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature