NT-proBNP and troponin T and risk of rapid kidney function decline and incident CKD in elderly adults.

ABSTRACT:

Background and objectives

Elevations in N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T are associated with poor cardiovascular outcomes. Whether elevations in these cardiac biomarkers are associated with decline in kidney function was evaluated.

Design, setting, participants, & measurements

N-terminal pro-B-type natriuretic peptide and troponin T were measured at baseline in 3752 participants free of heart failure in the Cardiovascular Health Study. eGFR was determined from the Chronic Kidney Disease Epidemiology Collaboration equation using serum cystatin C. Rapid decline in kidney function was defined as decline in serum cystatin C eGFR≥30%, and incident CKD was defined as the onset of serum cystatin C eGFR<60 among those without CKD at baseline

SUBMITTER: Bansal N 

PROVIDER: S-EPMC4317737 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature