No increase in IgG4-positive plasma cells in limbal Rosai-Dorfman disease.

ABSTRACT:

Purpose

Extranodal Rosai-Dorfman disease is a rare benign condition recently reported to sometimes show features of IgG4-related disease. The purpose of this study was to describe the corneal-limbal manifestation of the entity and to investigate whether numerous IgG4-positive plasma cells are associated with the disease at this site.

Methods

This is an interventional retrospective small case series.

Results

Two patients presenting with painless limbal mass lesions underwent total excisional biopsy with anterior lamellar keratoplasty for diagnostic and therapeutic purposes. Histopathologic evaluation of the specimens revealed inflammatory lesions containing atypical S100-immunoreactive histiocytes diagnostic of Rosai-Dorfman disease, but not an increase in the IgG4-pos

SUBMITTER: AlWadani S 

PROVIDER: S-EPMC4318238 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature