Acute alcohol modulates cardiac function as PI3K/Akt regulates oxidative stress.

ABSTRACT:

Background

Clinical manifestations of alcohol abuse on the cardiac muscle include defective contractility with the development of heart failure. Interestingly, low alcohol consumption has been associated with reduced risk of cardiovascular disease. Although several hypotheses have been postulated for alcoholic cardiomyopathy and for the low-dose beneficial cardiovascular effects, the precise mechanisms and mediators remain largely undefined. We hypothesize that modulation of oxidative stress by PI3K/Akt plays a key role in the cardiac functional outcome to acute alcohol exposure.

Methods

Thus, acutely exposed rat cardiac tissue and cardiocytes to low (LA: 5 mM), moderate (MA: 25 mM), and high (HA: 100 mM) alcohol were assessed for markers of oxidative stress in the presence

SUBMITTER: Umoh NA 

PROVIDER: S-EPMC4318499 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature