Ontology highlight
ABSTRACT:
SUBMITTER: Tsai HY
PROVIDER: S-EPMC4318647 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Cell 20150101 3
Effective silencing by RNA-interference (RNAi) depends on mechanisms that amplify and propagate the silencing signal. In some organisms, small-interfering RNAs (siRNAs) are amplified from target mRNAs by RNA-dependent RNA polymerase (RdRP). Both RdRP recruitment and mRNA silencing require Argonaute proteins, which are generally thought to degrade RNAi targets by directly cleaving them. However, in C. elegans, the enzymatic activity of the primary Argonaute, RDE-1, is not required for silencing a ...[more]