The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study.

ABSTRACT:

Background

Few studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as obsessive-compulsive symptoms (OCS).

Methods

The Schedule of Compulsions and Obsessions Patient Inventory (SCOPI) was administered to 104 patients with early-onset PD and 257 asymptomatic first-degree relatives. Carriers of one and two PARKIN mutations were compared with noncarriers.

Results

Among patients, carriers scored lower than noncarriers in adjusted models (one-mutation: 13.9 point difference, P = 0.03; two-mutation: 24.1, P = 0.001), wh

SUBMITTER: Sharp ME 

PROVIDER: S-EPMC4318772 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature