Both rare and common variants in PCSK9 influence plasma low-density lipoprotein cholesterol level in American Indians.

ABSTRACT:

Context

Elevated LDL cholesterol (LDL-C) is an important risk factor for atherosclerosis and cardiovascular disease. Variants in the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene have been associated not only with plasma LDL-C concentration, but also with ischemic heart disease. Little is known about the genetic architecture of PCSK9 and its influence on LDL-C in American Indians.

Objective

We aimed to investigate the genetic architecture in the 1p32 region encompassing PCSK9 and its influence on LDL-C in American Indians.

Design

The Strong Heart Family Study (SHFS) is a family-based genetic study.

Participants

Two thousand four hundred fifty eight American Indians from Arizona, Oklahoma, North Dakota, and South Dakota, who were genotyped by Illumi

SUBMITTER: Tsai CW 

PROVIDER: S-EPMC4318886 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature