Reduced serum levels of anti-Mullerian hormone in females with inherited bone marrow failure syndromes.

ABSTRACT:

Context

Previously, reduced levels of anti-Müllerian hormone (AMH), a circulating marker of ovarian reserve, were found in females with Fanconi anemia (FA). FA, dyskeratosis congenita (DC), and Diamond-Blackfan anemia (DBA) are inherited bone marrow failure syndromes (IBMFS) associated with high risks of bone marrow failure, leukemia, and solid tumors.

Objective

The objective of the study was to assess AMH levels in females with DC or DBA.

Design and setting

This observational study used the National Cancer Institute's inherited bone marrow failure syndrome cohort at the National Institutes of Health Clinical Center.

Participants

The study included females with DC, unaffected female relatives of patients with DC, females with DBA, unaffected female relatives of

SUBMITTER: Sklavos MM 

PROVIDER: S-EPMC4318906 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature