Symptomatic and asymptomatic respiratory viral infections in the first year of life: association with acute otitis media development.

ABSTRACT:

Background

Sensitive diagnostic assays have increased the detection of viruses in asymptomatic individuals. The clinical significance of asymptomatic respiratory viral infection in infants is unknown.

Methods

High-throughput, quantitative polymerase chain reaction assays were used to detect 13 common respiratory viruses from nasopharyngeal specimens collected during 2028 visits from 362 infants followed from near birth up to 12 months of age. Specimens were collected at monthly interval (months 1-6 and month 9) and during upper respiratory tract infection (URTI) episodes. Subjects were followed closely for acute otitis media (AOM) development.

Results

Viruses were detected in 76% of 394 URTI specimens and 27% of asymptomatic monthly specimens. Rhinovirus was detected

SUBMITTER: Chonmaitree T 

PROVIDER: S-EPMC4318943 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature