Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling.

ABSTRACT: Osteoclasts are bone-resorbing cells that are important for maintenance of bone remodeling and mineral homeostasis. Regulation of osteoclast differentiation and activity is important for the pathogenesis and treatment of diseases associated with bone loss. Here, we demonstrate that retinoid X receptors (RXRs) are key elements of the transcriptional program of differentiating osteoclasts. Loss of RXR function in hematopoietic cells resulted in formation of giant, nonresorbing osteoclasts and increased bone mass in male mice and protected female mice from bone loss following ovariectomy, which induces osteoporosis in WT females. The increase in bone mass associated with RXR deficiency was due to lack of expression of the RXR-dependent transcription factor v-maf musculoaponeurotic fibrosarcom

SUBMITTER: Menendez-Gutierrez MP 

PROVIDER: S-EPMC4319420 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature