Mathematical modeling of the insulin signal transduction pathway for prediction of insulin sensitivity from expression data.

ABSTRACT: Mathematical models of biological pathways facilitate a systems biology approach to medicine. However, these models need to be updated to reflect the latest available knowledge of the underlying pathways. We developed a mathematical model of the insulin signal transduction pathway by expanding the last major previously reported model and incorporating pathway components elucidated since the original model was reported. Furthermore, we show that inputting gene expression data of key components of the insulin signal transduction pathway leads to sensible predictions of glucose clearance rates in agreement with reported clinical measurements. In one set of simulations, our model predicted that glycerol kinase knockout mice have reduced GLUT4 translocation, and consequently, reduced glucose up

SUBMITTER: Ho CK 

PROVIDER: S-EPMC4319670 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature