Montage matters: the influence of transcranial alternating current stimulation on human physiological tremor.

ABSTRACT:

Background

Classically, studies adopting non-invasive transcranial electrical stimulation have placed greater importance on the position of the primary "stimulating" electrode than the secondary "reference" electrode. However, recent current density modeling suggests that ascribing a neutral role to the reference electrode may prove an inappropriate oversimplification.

Hypothesis

We set out to test the hypothesis that the behavioral effects of transcranial electrical stimulation are critically dependent on the position of the return ("reference") electrode.

Methods

We examined the effect of transcranial alternating current stimulation (sinusoidal waveform with no direct current offset at a peak-to-peak amplitude of 2000 μA and a frequency matched to each participant's

SUBMITTER: Mehta AR 

PROVIDER: S-EPMC4319690 | biostudies-literature | 2015 Mar-Apr

REPOSITORIES: biostudies-literature