A systematic review concerning the relation between the sympathetic nervous system and heart failure with preserved left ventricular ejection fraction.

ABSTRACT:

Background

Heart failure with preserved left ventricular ejection fraction (HFPEF) affects about half of all patients diagnosed with heart failure. The pathophysiological aspect of this complex disease state has been extensively explored, yet it is still not fully understood. Since the sympathetic nervous system is related to the development of systolic HF, we hypothesized that an increased sympathetic nerve activation (SNA) is also related to the development of HFPEF. This review summarizes the available literature regarding the relation between HFPEF and SNA.

Methods and results

Electronic databases and reference lists through April 2014 were searched resulting in 7722 unique articles. Three authors independently evaluated citation titles and abstracts, resulting in 77 art

SUBMITTER: Verloop WL 

PROVIDER: S-EPMC4319815 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature